Extensive accumulation of diazepam and its important metabolite, desmethyldiazepam, has actually been mentioned next chronic administration of diazepam in nutritious elderly male subjects. Metabolites of the drug are regarded for being significantly excreted through the kidney, and the potential risk of toxic reactions may be larger in patients with impaired renal function.

The potential risk of dependence boosts with duration of treatment; It is additionally higher in patients with a historical past of alcohol or drug abuse.

As a consequence of inconsistencies amongst the drug labels on DailyMed as well as the pill images supplied by RxImage, we no longer Exhibit the RxImage pill pictures affiliated with drug labels.

There are actually experiences of falls and fractures in benzodiazepine people. The risk is increased in People taking concomitant sedatives (together with alcohol) and from the elderly.

Alcohol or medications that result in sedation could insert into the sedative effects of diazepam. Patients taking benzodiazepines must avoid these kinds of combinations.

Some groups of consumers are in a higher risk of dependence than others. Folks with a heritage of substance abuse and other people with intense temperament Diseases. [twelve]

Tolerance on the therapeutic effect of diazepam tablets could create; however, small tolerance develops to the amnestic reactions and other cognitive impairments caused by benzodiazepines. OVERDOSAGE

Before you take VALIUM, convey to your Health care service provider about your whole medical ailments, together with if you: have or have experienced depression, mood challenges, or suicidal feelings or behavior

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Agitation black, tarry stools blistering, flaking, or peeling from the skin blurred vision variations in designs and rhythms of speech improvements in eyesight chills confusion cough darkish urine lessen from the frequency of urination minimize in urine quantity problems in passing urine (dribbling) discouragement dizziness, faintness, or lightheadedness when acquiring up abruptly from a lying or sitting situation Wrong beliefs that can not be adjusted by info fast heartbeat fast or irregular respiratory feeling unfortunate or vacant emotion that others are watching you or managing your actions experience that others can hear your thoughts emotion, looking at, or Listening to items that are not there fever headache hyperexcitability enhanced muscle spasms or tone irritability itching or rash not enough memory of what takes area right after a specific event loss of urge for food loss of bladder Regulate loss of curiosity or enjoyment loss of eyesight lower back or side pain nausea nightmares outbursts of anger painful or hard urination pale pores and skin restlessness seizures slurred speech sore throat belly pain perspiring difficulty concentrating problems sleeping difficulties Talking ulcers, sores, or white spots within the mouth uncomfortable breath odor unusual habits unusual bleeding or bruising unusual experience of pleasure diazepam gel unusual tiredness or weak spot vomiting of blood yellow eyes or skin Get emergency help immediately if any of the subsequent symptoms of overdose manifest:

a child is limp, floppy or not responding like they normally do (their head may fall into the side, backwards or forwards, or They could uncover it challenging to carry their head or target your deal with)

Normal If diazepam tablets are for being put together with other psychotropic agents or anticonvulsant drugs, mindful consideration should be presented into the pharmacology with the agents to become utilized - particularly with acknowledged compounds which will potentiate the action of diazepam, including phenothiazines, narcotics, barbiturates, MAO inhibitors and other antidepressants (see Drug Interactions). The usual safety measures are indicated for seriously frustrated patients or All those in whom There's any evidence of latent depression or anxiety affiliated with depression, especially the recognition that suicidal tendencies can be existing and protective measures might be required. Psychiatric and paradoxical reactions are regarded to occur when making use of benzodiazepines (see ADVERSE REACTIONS).

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Grapefruit might interact with diazepam and bring on undesired side effects. Stay away from the use of grapefruit merchandise.